Scientist I in Intestinal Physiology and Carcinogenesis

University of Kentucky
Lexington, Kentucky
Sep 29, 2020
Sep 29, 2021
Full Time
Position Type

Markey Cancer Center, University of Kentucky

Overview: The University of Kentucky Markey Cancer Center (MCC) is proud to be Kentucky’s only National Cancer Institute-designated cancer center located in beautiful Lexington, Kentucky.  The University of Kentucky is one of only a few universities in the country to have its undergraduate, medical and graduate colleges (16 total) and a nationally-recognized medical center and hospital on one central campus which allows for unique multidisciplinary collaborations.  The MCC, consistently ranked in the top 50 cancer centers in the country by US News and World Report, is dedicated to driving a measurable reduction in cancer incidence and mortality in Kentucky through a comprehensive program of cancer research, prevention, community outreach, education and patient care.

We are currently recruiting a Scientist I to work within a team of talented multidisciplinary investigators on projects focused on the physiologic and pathophysiologic effects of the intestinal hormone neurotensin on obesity, fat metabolism, and mechanisms of obesity-associated cancers.

Key Responsibilities Include:

The newly hired Scientist I will work under the direction of the Principal Investigators and other senior laboratory personnel.  Scientists will lead their projects and also have the opportunity to interact and collaborate with the rich community of basic and translational scientists at the MCC.  In addition, candidates will be expected to write and submit manuscripts based on their findings and assist with grant applications.  They will be involved in the following techniques and duties:

  • The project on the intestinal hormone neurotensin (NT) will extend novel findings published in Nature (Li, J et al. An obligatory role for neurotensin in high fat diet-induced obesity. Nature 533:411-415, 2016) identifying NT as an important contributor to obesity associated with consumption of a high fat diet. In addition, elevation of pro-NT levels serves as a marker for future obesity.  The Scientist will utilize multiple genetic mouse models, mouse and human intestinal organoid cultures, patient samples, Drosophila models, and other in vivo and in vitro model systems to identify the molecular mechanisms for fat deposition and fat metabolism associated with the increased release of NT.  The project will further explore the biologic and clinical implications of NT on fat inflammation and as a potentially important link to obesity-associated cancers.

Other highlights of the program include:

  • In addition to the research, the position will have a focus on career development including grant writing, scientific writing/presentation, mentorship of graduate students and technicians, networking, and building collaborations.

Qualifications, experience and skills required for consideration:

  • A Master’s degree in life or biomedical sciences, or a related discipline is required;
  • Ability to drive an individual project with scientific rigor, but also be highly collaborative with other academic partners;
  • Candidate should be highly self-motivated and organized, have a strong work ethic and desire to learn, and a proven track record of productivity;
  • Previous experience with mouse models, cancer biology, and cellular and molecular biology is highly desired.

Applicants must include:

  • Cover letter discussing their interest in the position, research interests and long-term goals
  • Curriculum Vitae
  • Contact information for three references
  • Academic Transcript

The University of Kentucky is an Equal Opportunity University that values diversity and inclusion. Individuals with disabilities, minorities, veterans, women, and members of other underrepresented groups are encouraged to apply.

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